Endocrine Abstracts

Introduction: Spindle cell oncocytoma (SCO), pituicytoma, granular cell tumor, and sellar ependymoma are rare TTF-1 positive posterior pituitary tumors classified as WHO Grade I, indicating low proliferative potential and high rates of surgical cure.Aims: To report a case of SCO and review the pertinent literature.Methods: English and non-English literature was searched, clinical, data were retrieved and summarized.<p class="ab...

Vitamin D receptors (VDRs) are expressed in bone and vascular cells which also respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis and energy metabolism measured by CK specific activity. We have previously observed that vitamin D-related compounds target several genes which affect cell proliferation, including mRNA expression of estrogen receptor (ER)α, ERβ, VDR, 1α hydroxylase of 25OHD3 (1OHase) and 12 and 15 lipoxygenas...

We have recently explored the involvement of ghrelin in the eating response to stress in humans and found that ghrelin levels increased in parallel to cortisol after a standardized psychological stress. To further elucidate this interaction, we examined the ghrelin response to pharmacological manipulation of the HPA axis.Following approval from the local Ethical Committee, six lean, healthy male volunteers were examined on two occasions. Blood samples we...

Background and aim of study: Endocrinologists play a central role in the gender affirming process that transgender people chose to undergo, and may be ill-prepared to recognize and manage psychologic difficulties that accompany gender dysphoria. We sought to characterize the patient population currently under our care with respect to their mental health, and to address the question of possible differences between transwomen (TW) and transmen (TM).Methods...

Several studies indicated that estrogen receptors (ERs) and vitamin D receptor (VDR), as well 1α-hydroxylase 25-hydroxy vitamin D (1OHase) are expressed in various normal and cancerous cell types. To date, there are no reported studies on the different expressions of VDR, 1OHase and ERs, in human thyroid normal and cancer cells. This study addresses these questions. Tissues harvested from papillary thyroid cancer (PTC) and normal glands explants were used throughout eithe...

Oestradiol-17β regulates diverse tissues and cells, both within and outside the reproductive system including human cancer cells. Currently used ERs agonists or antagonists are synthetic compounds prepared by structure modifications. Alternatively, peptide mimics of steroids would allow preparation of biased combinatorial libraries of chemical and biological origin, from which estrogenic peptides with tissue selective profiles can be selected. The phage-display peptide li...

Background: True Cushing’s syndrome (CS) is an exceedingly rare condition, thus to avoid unnecessary and costly testing, a diagnostic investigation should only start based on solid clinical suspicion. The current obesity epidemic has become a hurdle in discriminating subjects at real risk for CS from those with the metabolic syndrome. Moreover, many CS patientsrecently diagnosed do not fit the typical clinical profile of ‘at risk subjects’.<p class="abste...

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors decrease the degradation of low–density lipoprotein (LDL) receptors, thereby increasing the removal of LDL particles from the blood and significantly reducing LDL cholesterol levels by an average of 65%. Blom et al. showed changes in vitamin E, adrenocorticotropic hormone (ACTH), cortisol, total testosterone, and estradiol in EVOLOCUMAB (PCSK9 inhibitor)–treated patients 1. Ther...

Background: Although successful pregnancies carried by transgender men have been reported, long-term effects of testosterone therapy on fertility remain unknown.Aims: To study markers of ovarian reserve during testosterone therapy.Methods: Prospective open-label study of transgender men prior and during treatment with testosterone. Sampling was conducted at baseline and 12 months after treatment initiation.Ma...

As optimal postoperative management of patients with clinically nonfunctioning pituitary adenomas (NFPA) is a matter of debate, the role of dopamine agonist (DA) therapy in this clinical setting was evaluated.Methods: Retrospective analysis of prospectively collected data was conducted at two pituitary referral centrer with different standard practices for post-operative management of NFPA: DA therapy or conservative follow up. Dopamine receptor 2 (D2R) ...